Ataxin 3 antibody (N-Term)

Catalog No. ABIN2784210

The Rabbit Polyclonal anti-Ataxin 3 antibody is suitable to detect Ataxin 3 in samples from Human, Rat, Mouse, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for Ataxin 3 antibody (N-Term) (ABIN2784210)

Target: Ataxin 3 (ATXN3)

Reactivity: Human, Rat, Mouse, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ataxin 3 Antibody

Binding Specificity: N-Term

Purpose: ATXN3 Antibody - N-terminal region

Sequence: SIAHQLDEEE RMRMAEGGVT SEDYRTFLQQ PSGNMDDSGF FSIQVISNAL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ATXN3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50507-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ataxin 3

Target: Ataxin 3 (ATXN3)

Alternative Name: ATXN3

Background:

Background Information: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: Ataxin 3

Alternative Symbols: AT3, JOS, MJD, ATX3, MJD1, SCA3

Protein Name: Ataxin-3

Molecular Weight: 41kDa

Gene ID: 4287

NCBI Accession: NP_004984

UniProt: P54252