APC2 antibody (Middle Region)

Catalog No. ABIN2784219

This anti-APC2 antibody is a Rabbit Polyclonal antibody detecting APC2 in WB and IHC. Suitable for Human, Mouse, Rat, Dog, Cow and Guinea Pig.

Quick Overview for APC2 antibody (Middle Region) (ABIN2784219)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-APC2 Antibody

Binding Specificity: Middle Region

Sequence: LAVARIDQLV EDISALHTSS DDSFSLSSGD PGQEAPREGR AQSCSPCRGP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against APC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2303 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2

Background: APC2 belongs to the adenomatous polyposis coli (APC) family. It contains 6 ARM repeats. APC2 promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. It may function in Wnt signaling.
Alias Symbols: APCL
Protein Interaction Partner: CTNNB1, NFX1, UBC, CDC27, ANAPC4, ANAPC10, CDC16, CDC23, ANAPC11, ANAPC7, ANAPC5, CDC26, CDH1, ANAPC1, MAPRE3, MAPRE1, Axin1, AXIN2, ACTA1,
Protein Size: 2303

Molecular Weight: 244 kDa

Gene ID: 10297

NCBI Accession: NM_005883, NP_005874

UniProt: Q9UJX6

Pathways: WNT Signaling