APC2 antibody (AA 2041-2181)

Catalog No. ABIN5611232

Product Details anti-APC2 Antibody

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Binding Specificity: AA 2041-2181

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APC2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. coli.

Clone: 3A2G2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2 (APC2 Products)

Synonyms: APCL antibody, AI852447 antibody, R75424 antibody, APC2, WNT signaling pathway regulator antibody, adenomatosis polyposis coli 2 antibody, APC2 antibody, Apc2 antibody

Background:

Description: This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

Aliases: APCL

Molecular Weight: 244 kDa

Gene ID: 10297

HGNC: 10297

Pathways: WNT Signaling