SENP6 antibody (C-Term)

Catalog No. ABIN2784244

The Rabbit Polyclonal anti-SENP6 antibody is suitable to detect SENP6 in samples from Human, Mouse, Rat, Cow, Horse, Pig, Dog and Rabbit. It has been validated for WB.

Quick Overview for SENP6 antibody (C-Term) (ABIN2784244)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SENP6 Antibody

Binding Specificity: C-Term

Purpose: Senp6 Antibody - C-terminal region

Sequence: LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50599-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: Senp6

Background:

Background Information: Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene Name: SUMO/sentrin specific peptidase 6

Alternative Symbols: Susp1, mKIAA0797, 2810017C20Rik, E130319N12Rik

Protein Name: Sentrin-specific protease 6

Molecular Weight: 127kDa

Gene ID: 215351

NCBI Accession: NP_666115

UniProt: Q6P7W0