Retinoblastoma Binding Protein 8 antibody (C-Term)

Catalog No. ABIN2784374

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 8 antibody has been validated for WB. It is suitable to detect Retinoblastoma Binding Protein 8 in samples from Human, Pig, Cow, Dog, Rabbit, Guinea Pig and Horse.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (C-Term) (ABIN2784374)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human, Pig, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Binding Specificity: C-Term

Sequence: ETVDMDCTLV SETVLLKMKK QEQKGEKSSN EERKMNDSLE DMFDRTTHEE

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 83%, Horse: 79%, Human: 100%, Pig: 100%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 867 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8

Background: RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Alias Symbols: CTIP, RIM, JWDS, SAE2, SCKL2
Protein Interaction Partner: LMO4, PIN1, LMO1, MDM2, BRCA1, RBL1, TMEM54, PRRG4, RGS17, IKBKG, IGFBP7, EEF1A1, CTBP2, CLU, MAP2K4, RAF1, RBL2, PCNA, ZNF350, NBN, UIMC1, PALB2, BARD1, SPEN, RAD50, CTBP1, RB1, UBC, FXR2, RBBP8, IKZF1, LIMS1, SIAH2, SIAH1, LMO2, WDYHV1, ATM, TGIF2, IKZF
Protein Size: 867

Molecular Weight: 98 kDa

Gene ID: 5932

NCBI Accession: NM_203292, NP_976037

UniProt: A6NKN2

Pathways: Cell Division Cycle, DNA Damage Repair