DYNLL1 antibody (Middle Region)

Catalog No. ABIN2784485

The Rabbit Polyclonal anti-DYNLL1 antibody is suitable to detect DYNLL1 in samples from Human, Mouse, Rat, Horse, Rabbit, Guinea Pig, Dog, Cow, Zebrafish (Danio rerio) and Goat. It has been validated for WB.

Quick Overview for DYNLL1 antibody (Middle Region) (ABIN2784485)

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Guinea Pig, Dog, Cow, Zebrafish (Danio rerio), Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNLL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DYNLL1 Antibody

Binding Specificity: Middle Region

Purpose: DYNLL1 Antibody - middle region

Sequence: EKDIAAHIKK EFDKKYNPTW HCIVGRNFGS YVTHETKHFI YFYLGQVAIL

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against DYNLL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DYNLL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP51261-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DYNLL1

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Alternative Name: DYNLL1

Background:

Background Information: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Gene Name: Dynein, light chain, LC8-type 1

Alternative Symbols: LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1

Protein Name: Dynein light chain 1, cytoplasmic

Molecular Weight: 10kDa

Gene ID: 8655

NCBI Accession: NP_001032583

UniProt: P63167

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity