This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene.
Alias Symbols: EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3
Protein Interaction Partner: SIAH1, FAM127C, LDOC1, CALCOCO2, FAM127A, UBC, MAPT, HNRNPUL1, HNRNPH1, BAG1, TGFBR2, TGFBR1, BMPR1B, BMPR1A, ACVRL1, ACVR2B, ACVR2A, ACVR1B, ACVR1, RNF2, ZNF512B, RNF181, HMGCS1, TOLLIP, IRF4, SIAH2,
Protein Size: 401