FGL2 antibody (Middle Region)

Catalog No. ABIN2784837

This Rabbit Polyclonal antibody specifically detects FGL2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Pig, Cow, Guinea Pig and Rabbit and has been mentioned in 2+ publications.

Quick Overview for FGL2 antibody (Middle Region) (ABIN2784837)

Target: FGL2 (Fibrinogen-Like 2 (FGL2))

Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGL2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGL2 Antibody

Binding Specificity: Middle Region

Sequence: WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FGL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 439 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FGL2 antibody (ABIN2784837)

Pischke, Gustavsen, Orrem, Egge, Courivaud, Fontenelle, Despont, Bongoni, Rieben, Tønnessen, Nunn, Scott, Skulstad, Barratt-Due, Mollnes: "Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function." in: Basic research in cardiology, Vol. 112, Issue 3, pp. 20, (2017) (PubMed).

Bongoni, Klymiuk, Wolf, Ayares, Rieben, Cowan: "Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation." in: Transplantation, Vol. 100, Issue 9, pp. 1871-9, (2016) (PubMed).

Target Details for FGL2

Target: FGL2 (Fibrinogen-Like 2 (FGL2))

Alternative Name: FGL2

Background: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.
Alias Symbols: T49, pT49
Protein Size: 439

Molecular Weight: 48 kDa

Gene ID: 10875

NCBI Accession: NM_006682, NP_006673

UniProt: Q14314