NEURL2 antibody (N-Term)

Catalog No. ABIN2784965

Product Details anti-NEURL2 Antibody

Target: NEURL2 (Neuralized Homolog 2 (NEURL2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEURL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAAASEPVDS GALWGLERPE PPPTRFHRVH GANIRVDPSG TRATRVESFA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NEURL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NEURL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 285 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NEURL2

Target: NEURL2 (Neuralized Homolog 2 (NEURL2))

Alternative Name: NEURL2 (NEURL2 Products)

Synonyms: C20orf163 antibody, OZZ antibody, OZZ-E3 antibody, Neur2 antibody, Ozz antibody, Ozz-E3 antibody, neuralized E3 ubiquitin protein ligase 2 antibody, NEURL2 antibody, Neurl2 antibody

Background: NEURL2 contains 1 NHR (neuralized homology repeat) domain and 1 SOCS box domain. NEURL2 plays an important role in the process of myofiber differentiation and maturation. NEURL2 is the probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, it controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
Alias Symbols: C20orf163, MGC125934, MGC125935, OZZ, Ozz-E3
Protein Interaction Partner: CTNNB1,
Protein Size: 285

Molecular Weight: 32 kDa

Gene ID: 140825

NCBI Accession: NM_080749, NP_542787

UniProt: Q9BR09