LCA5 antibody (N-Term)

Catalog No. ABIN2785382

This Rabbit Polyclonal antibody specifically detects LCA5 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit and Cow.It has been mentioned in 1 publication

Quick Overview for LCA5 antibody (N-Term) (ABIN2785382)

Target: LCA5 (Leber Congenital Amaurosis 5 (LCA5))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCA5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LCA5 Antibody

Binding Specificity: N-Term

Purpose: LCA5 Antibody - N-terminal region

Sequence: FSLQKLKEIS EARHLPERDD LAKKLVSAEL KLDDTERRIK ELSKNLELST

Predicted Reactivity: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LCA5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LCA5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104180

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-LCA5 antibody (ABIN2785382)

Ramprasad, Soumittra, Nancarrow, Sen, McKibbin, Williams, Arokiasamy, Lakshmipathy, Inglehearn, Kumaramanickavel: "Identification of a novel splice-site mutation in the Lebercilin (LCA5) gene causing Leber congenital amaurosis." in: Molecular vision, Vol. 14, pp. 481-6, (2008) (PubMed).

Target Details for LCA5

Target: LCA5 (Leber Congenital Amaurosis 5 (LCA5))

Alternative Name: LCA5

Background:

Background Information: LCA5 is a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternative splicing results in two transcript variants.

Gene Name: Leber congenital amaurosis 5

Alternative Symbols: C6orf152

Protein Name: Lebercilin

Molecular Weight: 80kDa

Gene ID: 167691

NCBI Accession: NP_859065

UniProt: Q86VQ0