GSTM3 antibody (Middle Region)

Catalog No. ABIN2785444

The Rabbit Polyclonal anti-GSTM3 antibody is suitable to detect GSTM3 in samples from Human, Mouse, Rat, Cow, Dog, Pig, Rabbit and Horse. It has been validated for WB.

Quick Overview for GSTM3 antibody (Middle Region) (ABIN2785444)

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTM3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GSTM3 Antibody

Binding Specificity: Middle Region

Purpose: GSTM3 Antibody - middle region

Sequence: EEKIRVDIIE NQVMDFRTQL IRLCYSSDHE KLKPQYLEEL PGQLKQFSMF

Predicted Reactivity: Cow: 85%, Dog: 77%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 92%, Rabbit: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against GSTM3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GSTM3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101685

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GSTM3

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Alternative Name: GSTM3

Background:

Background Information: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM3 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Glutathione S-transferase mu 3 (brain)

Alternative Symbols: GST5, GSTB, GTM3, GSTM3-3

Protein Name: Glutathione S-transferase Mu 3

Molecular Weight: 27 kDa

Gene ID: 2947

NCBI Accession: NP_000840

UniProt: P21266