GRK4 antibody (Middle Region)

Catalog No. ABIN2785447

This Rabbit Polyclonal antibody specifically detects GRK4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Dog, Guinea Pig and Rabbit.

Quick Overview for GRK4 antibody (Middle Region) (ABIN2785447)

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRK4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRK4 Antibody

Binding Specificity: Middle Region

Purpose: GRK4 Antibody - middle region

Sequence: QSRFVVSLAY AYETKDALCL VLTIMNGGDL KFHIYNLGNP GFDEQRAVFY

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against GRK4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GRK4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101178

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GRK4

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Alternative Name: GRK4

Background:

Background Information: GRK4 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. GRK4 has been linked to both genetic and acquired hypertension.This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.

Gene Name: G protein-coupled receptor kinase 4

Alternative Symbols: IT11, GPRK4, GRK4a, GPRK2L

Protein Name: G protein-coupled receptor kinase 4

Molecular Weight: 59kDa

Gene ID: 2868

NCBI Accession: NP_001004057

UniProt: P32298

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling