GLA antibody (N-Term)

Catalog No. ABIN2785641

The Rabbit Polyclonal anti-GLA antibody has been validated for WB. It is suitable to detect GLA in samples from Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Goat, Rabbit and Zebrafish (Danio rerio).

Quick Overview for GLA antibody (N-Term) (ABIN2785641)

Target: GLA (Galactosidase, alpha (GLA))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Goat, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GLA Antibody

Binding Specificity: N-Term

Sequence: PQRFPHGIRQ LANYVHSKGL KLGIYADVGN KTCAGFPGSF GYYDIDAQTF

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against GLA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GLA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 429 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GLA

Target: GLA (Galactosidase, alpha (GLA))

Alternative Name: GLA

Background: GLA is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GALA
Protein Interaction Partner: ZNF622, CNDP2, MAT2B, EIF4H, PGD, GNS, GBP2, G6PD, EIF5, CAPN1, ALDH7A1, TERT, UBC, FBXO6, OTUD4, GLA,
Protein Size: 429

Molecular Weight: 45 kDa

Gene ID: 2717

NCBI Accession: NM_000169, NP_000160

UniProt: P06280

Pathways: SARS-CoV-2 Protein Interactome