SH3KBP1 antibody (N-Term)

Catalog No. ABIN2785720

This Rabbit Polyclonal antibody specifically detects SH3KBP1 in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio).

Quick Overview for SH3KBP1 antibody (N-Term) (ABIN2785720)

Target: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3KBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SH3KBP1 Antibody

Binding Specificity: N-Term

Sequence: TGMFPSNFIK ELSGESDELG ISQDEQLSKS SLRETTGSES DGGDSSSTKS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against SH3KBP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SH3KBP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 628 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SH3KBP1

Target: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Alternative Name: SH3KBP1

Background: This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
Alias Symbols: CIN85, GIG10, MIG18, HSB1, HSB-1, CD2BP3
Protein Interaction Partner: PNMA5, ZBTB7B, SH3KBP1, STAP1, FRS3, SPRY2, ASAP2, PSMA3, CBL, UBC, RAF1, LOX, INPP5D, Dlg4, FAP, ARHGAP17, Ap2a1, Irf2bp1, Gcdh, Sept7, Wipf1, Chtf8, Cblb, Shkbp1, Rtkn2, Idh3b, Pik3ap1, Slc25a12, Wasl, Ap2b1, Arap1, Far1, Cltc, Timm50, Actn4, Sept6, Net
Protein Size: 628

Molecular Weight: 68 kDa

Gene ID: 30011

NCBI Accession: NM_001024666, NP_001019837

UniProt: Q5JPT5

Pathways: EGFR Signaling Pathway, EGFR Downregulation