NLRP1 antibody (N-Term)

Catalog No. ABIN2785731

The Rabbit Polyclonal anti-NLRP1 antibody has been validated for WB. It is suitable to detect NLRP1 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Pig and Rabbit.

Quick Overview for NLRP1 antibody (N-Term) (ABIN2785731)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NLRP1 Antibody

Binding Specificity: N-Term

Sequence: DTQEPRIVIL QGAAGIGKST LARQVKEAWG RGQLYGDRFQ HVFYFSCREL

Predicted Reactivity: Cow: 85%, Dog: 86%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 85%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NLRP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NLRP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1375 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: NLRP1

Background: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like
Alias Symbols: CARD7, CLR17.1, DEFCAP, DEFCAP-L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, PP1044, SLEV1, VAMAS1
Protein Interaction Partner: TRIM68, CUL3, APOA1, NLRP1, PYCARD, NOD1, CASP5, CASP9, APAF1, CASP2, BCL2L1, BCL2, CASP1, NLRC4,
Protein Size: 1375

Molecular Weight: 155 kDa

Gene ID: 22861

NCBI Accession: NM_001033053, NP_001028225

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome