Arylsulfatase A antibody (Middle Region)

Catalog No. ABIN2785758

Product Details anti-Arylsulfatase A Antibody

Target: Arylsulfatase A (ARSA)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Horse, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Arylsulfatase A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KQLQLLKAQL DAAVTFGPSQ VARGEDPALQ ICCHPGCTPR PACCHCPDPH

Predicted Reactivity: Cow: 79%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 86%, Pig: 92%, Rabbit: 79%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against ARSA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ARSA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 507 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Arylsulfatase A

Target: Arylsulfatase A (ARSA)

Alternative Name: ARSA (ARSA Products)

Synonyms: ARSA antibody, zgc:101575 antibody, arsa antibody, AS-A antibody, ASA antibody, AW212749 antibody, As-2 antibody, As2 antibody, TISP73 antibody, MLD antibody, mld antibody, arylsulfatase A antibody, arylsulfatase antibody, arylsulfatase A, gene 1 S homeolog antibody, ARSA antibody, arsa antibody, arsA antibody, RB6599 antibody, Arsa antibody, arsa.1.S antibody

Background: ARSA hydrolyzes cerebroside sulfate. Defects in ARSA are a cause of leukodystrophy metachromatic (MLD).The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene.
Alias Symbols: MLD
Protein Interaction Partner: TRIP13, PPIC, CETN2, CLEC4G, ARSA, GAL3ST1, BMPR2, CTSL,
Protein Size: 507

Molecular Weight: 52 kDa

Gene ID: 410

NCBI Accession: NM_001085427, NP_001078896

UniProt: P15289