EPS15 antibody (C-Term)

Catalog No. ABIN2785791

This Rabbit Polyclonal antibody specifically detects EPS15 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig and Rabbit.

Quick Overview for EPS15 antibody (C-Term) (ABIN2785791)

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPS15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EPS15 Antibody

Binding Specificity: C-Term

Sequence: LDSPDPFKLN DPFQPFPGND SPKEKDPEIF CDPFTSATTT TNKEADPSNF

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EPS15. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EPS15

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 896 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EPS15

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Alternative Name: EPS15

Background: EPS15 is a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias.This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AF-1P, AF1P, MLLT5
Protein Interaction Partner: TRIM63, UBC, GJA1, EPHA2, CORO7, RNF11, RABL6, OPTN, LAPTM5, VCAM1, ITGA4, FN1, Fcho2, Dab2, STON2, EPN1, AGFG1, EPS15, CRKL, CRK, AP2S1, AP2M1, AP2B1, AP1B1, AP2A2, AP2A1, ACTB, ABL1, NECAP1, SPG20, VPRBP, KRT75, IQGAP1, KRT36, KRT37, KRT38, CCT3, TRAF2,
Protein Size: 896

Molecular Weight: 99 kDa

Gene ID: 2060

NCBI Accession: NM_001981, NP_001972

UniProt: P42566

Pathways: EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation