FTH1 antibody (Middle Region)

Catalog No. ABIN2785803

Product Details anti-FTH1 Antibody

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Sheep, Dog, Rabbit, Horse, Guinea Pig, Cow, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FTH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: NVNQSLLELH KLATDKNDPH LCDFIETHYL NEQVKAIKEL GDHVTNLRKM

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against FTH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FTH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 183 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FTH1 antibody (ABIN2785803)

Potrykus, Stead, Maccallum, Urgast, Raab, van Rooijen, Feldmann, Brown: "Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events." in: PLoS pathogens, Vol. 9, Issue 10, pp. e1003676, (2013) (PubMed).

Target Details for FTH1

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Alternative Name: FTH1 (FTH1 Products)

Synonyms: FHC antibody, FTH antibody, FTHL6 antibody, PIG15 antibody, PLIF antibody, apoferritin antibody, ferritin antibody, fhc antibody, fth antibody, fth1 antibody, fthl6 antibody, ftn-2 antibody, pig15 antibody, plif antibody, fth1b antibody, Fth antibody, HFt antibody, MFH antibody, fb06g09 antibody, hm:zeh1145 antibody, wu:fb06g09 antibody, wu:fq18c10 antibody, zeh1145 antibody, ferritin heavy chain 1 antibody, ferritin, heavy polypeptide 1 L homeolog antibody, ferritin, heavy polypeptide 1 S homeolog antibody, ferritin heavy polypeptide 1 antibody, ferritin, heavy polypeptide 1a antibody, ferritin antibody, ferritin, heavy polypeptide 1 antibody, tudor domain containing 9 antibody, ferritin, heavy polypeptide 1 a antibody, FTH1 antibody, fth1.L antibody, fth1.S antibody, Fth1 antibody, fth1a antibody, EAMY_RS19690 antibody, fth1 antibody, TDRD9 antibody

Background: FTH1 is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FTH, FTHL6, MGC104426, PIG15, PLIF, FHC
Protein Interaction Partner: SDCBP, FTL, FTH1, WDYHV1, CEP57, AURKB, TP53, AURKA, ASB15, ASB16, SUPT16H, SET, MAPK9, MAX, IGSF8, TICAM2, HCVgp1, PIAS4, CDC16, YWHAE, SOX5, MYL3, LBP, KPNA2, GRB2, DAXX, CSNK2B, CDC25A, ATP6V1B1, CD99, SPP1, TRAF4, SUMO2, UBC, Cep55, Trim28, NR1I3, NR3
Protein Size: 183

Molecular Weight: 21 kDa

Gene ID: 2495

NCBI Accession: NM_002032, NP_002023

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis