KPNA3 antibody (N-Term)

Catalog No. ABIN2785825

Product Details anti-KPNA3 Antibody

Target: KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AENPSLENHR IKSFKNKGRD VETMRRHRNE VTVELRKNKR DEHLLKKRNV

Predicted Reactivity: Cow: 77%, Dog: 77%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against KPNA3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 521 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KPNA3

Target: KPNA3 (Karyopherin alpha 3 (Importin alpha 4) (KPNA3))

Alternative Name: KPNA3 (KPNA3 Products)

Synonyms: IPOA4 antibody, si:dz79f24.2 antibody, importin antibody, SRP1 antibody, SRP1gamma antibody, SRP4 antibody, hSRP1 antibody, ipoa4 antibody, srp1 antibody, srp1gamma antibody, srp4 antibody, karyopherin (importin) alpha 3 antibody, karyopherin alpha 3 (importin alpha 4) antibody, karyopherin subunit alpha 3 antibody, karyopherin alpha 3 (importin alpha 4) L homeolog antibody, Kpna3 antibody, kpna3 antibody, KPNA3 antibody, kpna3.L antibody

Background: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3 is a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggest that karyopherin alpha-3 may be involved in the nuclear transport system.The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IPOA4, SRP1gamma, SRP4, hSRP1, SRP1
Protein Interaction Partner: TEX37, SLC5A11, APOL6, RPRD1A, ZCCHC10, MAT2B, NUP50, TSSC4, ZBTB24, DDX21, MTA1, HNRNPC, FTL, MVP, HSF1, UBC, MMS19, KPNA6, MCM6, MCM4, HDAC1, UL122, NACC1, NFE2L2, MYOD1, GTF2H1, GATA6, ERCC3, EPHA2, CBX5, TP53BP1, BARD1, ZNF131, COIL, CUL3, Ranbp2, Mki
Protein Size: 521

Molecular Weight: 58 kDa

Gene ID: 3839

NCBI Accession: NM_002267, NP_002258

UniProt: O00505

Pathways: Protein targeting to Nucleus