KPNA5 antibody (C-Term)

Catalog No. ABIN2785826

This Rabbit Polyclonal antibody specifically detects KPNA5 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Pig and Zebrafish (Danio rerio).

Quick Overview for KPNA5 antibody (C-Term) (ABIN2785826)

Target: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KPNA5 Antibody

Binding Specificity: C-Term

Purpose: KPNA5 Antibody - C-terminal region

Sequence: TVMDSKIVQV ALNGLENILR LGEQESKQNG IGINPYCALI EEAYGLDKIE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 86%, Rat: 86%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against KPNA5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KPNA5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54679-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KPNA5

Target: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Alternative Name: KPNA5

Background:

Targeted Subunit: alpha-6

Background Information: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion, larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Karyopherin alpha 5 (importin alpha 6)

Alternative Symbols: SRP6, IPOA6

Protein Name: Importin subunit alpha-6

Molecular Weight: 61kDa

Gene ID: 3841

NCBI Accession: NP_002260

UniProt: O15131

Pathways: Protein targeting to Nucleus