LOXL1 antibody (N-Term)

Catalog No. ABIN2785878

This anti-LOXL1 antibody is a Rabbit Polyclonal antibody detecting LOXL1 in WB. Suitable for Human, Mouse, Rat, Cow, Rabbit, Guinea Pig and Horse. This Primary Antibody has been cited in 1 publication.

Quick Overview for LOXL1 antibody (N-Term) (ABIN2785878)

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LOXL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LOXL1 Antibody

Binding Specificity: N-Term

Sequence: RWRQLIQWEN NGQVYSLLNS GSEYVPAGPQ RSESSSRVLL AGAPQAQQRR

Predicted Reactivity: Cow: 83%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LOXL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LOXL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 574 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-LOXL1 antibody (ABIN2785878)

Ohmura, Yasukawa, Minami, Sugi, Oba, Nagata, Kyogoku, Ohshima, Aoki, Imaizumi: "Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice." in: Hypertension research : official journal of the Japanese Society of Hypertension, Vol. 35, Issue 11, pp. 1063-8, (2012) (PubMed).

Target Details for LOXL1

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Alternative Name: LOXL1

Background: LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: LOL, LOXL
Protein Interaction Partner: ATXN1, CUL2, FBLN5, ELN,
Protein Size: 574

Molecular Weight: 53 kDa

Gene ID: 4016

NCBI Accession: NM_005576, NP_005567

UniProt: Q08397