PHLDA1 antibody (Middle Region)

Catalog No. ABIN2785897

This Rabbit Polyclonal antibody specifically detects PHLDA1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Dog.It has been mentioned in 1 publication

Quick Overview for PHLDA1 antibody (Middle Region) (ABIN2785897)

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PHLDA1 Antibody

Binding Specificity: Middle Region

Sequence: PAVASLEPPV KLKELHFSNM KTVDCVERKG KYMYFTVVMA EGKEIDFRCP

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PHLDA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PHLDA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 401 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PHLDA1 antibody (ABIN2785897)

Tsuda, Davis, Argani, Shukla, McGill, Nagai, Saito, Laé, Fisher, Ladanyi: "TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition." in: Cancer research, Vol. 67, Issue 3, pp. 919-29, (2007) (PubMed).

Target Details for PHLDA1

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Alternative Name: PHLDA1

Background: PHLDA1 is an evolutionarily conserved proline-histidine rich nuclear protein. It may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.
Alias Symbols: DT1P1B11, MGC131738, PHRIP, TDAG51
Protein Interaction Partner: UBC, SUMO1, MDFI, EGFR, APP, DNAJB1, HSPB1, HSPA4, ELAVL1, KRTAP4-12, RPL14, PLSCR1, HSPA4L, EIF3D, PABPC4,
Protein Size: 401

Molecular Weight: 45 kDa

Gene ID: 22822

NCBI Accession: NM_007350, NP_031376

UniProt: Q8WV24