GTPBP4 antibody (C-Term)

Catalog No. ABIN2785935

The Rabbit Polyclonal anti-GTPBP4 antibody (ABIN2785935) specifically detects GTPBP4 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Guinea Pig samples.

Quick Overview for GTPBP4 antibody (C-Term) (ABIN2785935)

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTPBP4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GTPBP4 Antibody

Binding Specificity: C-Term

Purpose: GTPBP4 Antibody - C-terminal region

Sequence: MVKKAKTMMK NAQKKMNRLG KKGEADRHVF DMKPKHLLSG KRKAGKKDRR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GTPBP4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GTPBP4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54884-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GTPBP4

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Alternative Name: GTPBP4

Background:

Background Information: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.

Gene Name: GTP binding protein 4

Alternative Symbols: NGB, CRFG, NOG1

Protein Name: Nucleolar GTP-binding protein 1

Molecular Weight: 74kDa

Gene ID: 23560

NCBI Accession: NP_036473

UniProt: Q9BZE4