Cytohesin 4 antibody (N-Term)

Catalog No. ABIN2785970

The Rabbit Polyclonal anti-Cytohesin 4 antibody (ABIN2785970) specifically detects Cytohesin 4 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for Cytohesin 4 antibody (N-Term) (ABIN2785970)

Target: Cytohesin 4 (CYTH4)

Reactivity: Human, Mouse, Rat, Cow, Pig, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytohesin 4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cytohesin 4 Antibody

Binding Specificity: N-Term

Purpose: PSCD4 Antibody - N-terminal region

Sequence: NKTAIGTYLG ERDPINLQVL QAFVDCHEFA NLNLVQALRQ FLWSFRLPGE

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against PSCD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PSCD4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54947-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cytohesin 4

Target: Cytohesin 4 (CYTH4)

Alternative Name: PSCD4

Background:

Background Information: PSCD4 promotes guanine-nucleotide exchange on ARF1 and ARF5. PSCD4 promotes the activation of ARF through replacement of GDP with GTP.Pleckstrin homology, Sec7 and coiled/coil domains 4 (PSCD4) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The PSCD4 and PSCD1 gene structures are very similar.

Gene Name: Cytohesin 4

Alternative Symbols: CYT4, PSCD4, DJ63G5.1, cytohesin-4

Protein Name: Cytohesin-4

Molecular Weight: 46kDa

Gene ID: 27128

NCBI Accession: NP_037517

UniProt: Q9UIA0