OPTC antibody (C-Term)

Catalog No. ABIN503636

The Rabbit Polyclonal anti-OPTC antibody is suitable to detect OPTC in samples from Human, Mouse, Rat, Pig, Dog, Guinea Pig, Cow, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for OPTC antibody (C-Term) (ABIN503636)

Target: OPTC (Opticin (OPTC))

Reactivity: Human, Mouse, Rat, Pig, Dog, Guinea Pig, Cow, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OPTC Antibody

Binding Specificity: C-Term

Purpose: OPTC Antibody - C-terminal region

Sequence: LSDNLLDSIP GPLPLSLRSV HLQNNLIETM QRDVFCDPEE HKHTRRQLED

Predicted Reactivity: Cow: 77%, Dog: 100%, Guinea Pig: 85%, Horse: 92%, Human: 100%, Mouse: 85%, Pig: 100%, Rabbit: 92%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against OPTC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human OPTC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55034-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for OPTC

Target: OPTC (Opticin (OPTC))

Alternative Name: OPTC

Background:

Background Information: Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also ocalizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).

Gene Name: Opticin

Alternative Symbols: OPT

Protein Name: Opticin

Molecular Weight: 35kDa

Gene ID: 26254

NCBI Accession: NP_055174

UniProt: Q9UBM4