TMOD3 antibody (Middle Region)

Catalog No. ABIN2786043

The Rabbit Polyclonal anti-TMOD3 antibody is suitable to detect TMOD3 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for TMOD3 antibody (Middle Region) (ABIN2786043)

Target: TMOD3 (Tropomodulin 3 (TMOD3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMOD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TMOD3 Antibody

Binding Specificity: Middle Region

Purpose: TMOD3 Antibody - middle region

Sequence: ITNTKFCNIM GSSNGVDQEH FSNVVKGEKI LPVFDEPPNP TNVEESLKRT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against TMOD3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMOD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55078-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TMOD3

Target: TMOD3 (Tropomodulin 3 (TMOD3))

Alternative Name: TMOD3

Background:

Background Information: TMOD3 belongs to the tropomodulin family. It blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.

Gene Name: Tropomodulin 3 (ubiquitous)

Alternative Symbols: UTMOD

Protein Name: Tropomodulin-3

Molecular Weight: 39kDa

Gene ID: 29766

NCBI Accession: NP_055362

UniProt: Q9NYL9

Pathways: Regulation of Actin Filament Polymerization