KIFAP3 antibody (Middle Region)

Catalog No. ABIN2786068

The Rabbit Polyclonal anti-KIFAP3 antibody has been validated for WB. It is suitable to detect KIFAP3 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Dog.

Quick Overview for KIFAP3 antibody (Middle Region) (ABIN2786068)

Target: KIFAP3 (Kinesin Associated Protein 3 (KIFAP3))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIFAP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KIFAP3 Antibody

Binding Specificity: Middle Region

Sequence: WLEMVESRQM DESEQYLYGD DRIEPYIHEG DILERPDLFY NSDGLIASEG

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against KIFAP3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KIFAP3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 792 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIFAP3

Target: KIFAP3 (Kinesin Associated Protein 3 (KIFAP3))

Alternative Name: KIFAP3

Background: The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras, one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein.
Alias Symbols: FLJ22818, KAP3, SMAP, Smg-GDS, dJ190I16.1, KAP-3
Protein Interaction Partner: NAA10, NCF2, UBC, PEX19, RBFOX1, KIF3A, VHL, RANBP2, MEST, DISC1, NIPSNAP3A, NUDT21, AR, RAP1GDS1, MINK1, SMC3, KIF3B, KIFAP3, MAP3K10, RPGR, SRC, APC, MAP3K11,
Protein Size: 792

Molecular Weight: 91 kDa

Gene ID: 22920

NCBI Accession: NM_014970, NP_055785

UniProt: Q92845

Pathways: Hedgehog Signaling, Sensory Perception of Sound