CCDC11 antibody (N-Term)

Catalog No. ABIN406528

This Rabbit Polyclonal antibody specifically detects CCDC11 in WB. It exhibits reactivity toward Human, Guinea Pig, Horse, Pig, Cow and Dog. It has been mentioned in 2+ publications

Quick Overview for CCDC11 antibody (N-Term) (ABIN406528)

Target: CCDC11 (Coiled-Coil Domain Containing 11 (CCDC11))

Reactivity: Human, Guinea Pig, Horse, Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCDC11 Antibody

Binding Specificity: N-Term

Purpose: CFAP53 Antibody - N-terminal region

Sequence: YSQRFGTVQR EVKGPTPKVV IVRSKPPKGQ GAEHHLERIR RSHQKHNAIL

Predicted Reactivity: Cow: 93%, Dog: 79%, Guinea Pig: 77%, Horse: 85%, Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against CCDC11. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CCDC11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55454-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CCDC11 antibody (ABIN406528)

Perles, Cinnamon, Ta-Shma, Shaag, Einbinder, Rein, Elpeleg: "A human laterality disorder associated with recessive CCDC11 mutation." in: Journal of medical genetics, Vol. 49, Issue 6, pp. 386-90, (2012) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Target Details for CCDC11

Target: CCDC11 (Coiled-Coil Domain Containing 11 (CCDC11))

Alternative Name: CFAP53

Background:

Background Information: This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning.

Gene Name: cilia and flagella associated protein 53

Alternative Symbols: HTX6, CCDC11

Protein Name: cilia- and flagella-associated protein 53

Molecular Weight: 62kDa

Gene ID: 220136

NCBI Accession: NP_659457

UniProt: Q96M91