HIPK1 antibody (Middle Region)

Catalog No. ABIN2786406

Product Details anti-HIPK1 Antibody

Target: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIPK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PLNLSQNQQS SAAPTSQERS SNPAPRRQQA FVAPLSQAPY TFQHGSPLHS

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against HIPK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIPK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1210 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIPK1

Target: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Alternative Name: HIPK1 (HIPK1 Products)

Background: HIPK1 may play a role as a corepressor for homeodomain transcription factors. HIPK1 phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. HIPK1 may be involved in malignant squamous cell tumor formation.The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Alias Symbols: KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2
Protein Interaction Partner: FHL3, HIPK1, DDX54, HAX1, NEB, A2M, PRPF40A, UBC, SKIL, PARK7, ATP13A2, RASSF5, SIAH1, UBE2I, GLUL, SNIP1, DAXX, NKX2-5, TP53, RUNX1, HOXD4,
Protein Size: 1210

Molecular Weight: 131 kDa

Gene ID: 204851

NCBI Accession: NM_198268, NP_938009

UniProt: Q86Z02