HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (N-Term) antibody

Catalog No. ABIN2786479

Product Details

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Sequence: TGSPYSTNCW LCTSSSTETP GTAYPASPRE WTSIEAELHI SYRWDPNLKG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against HERV-FRD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 538 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References

Malassiné, Frendo, Blaise, Handschuh, Gerbaud, Tsatsaris, Heidmann, Evain-Brion: "Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta." in: Retrovirology, Vol. 5, pp. 6, (2008) (PubMed).

Target Details

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Alternative Name: HERV-FRD (Herv-frd Products)

Target Type: Viral Protein

Background: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8 % of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1, MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
Alias Symbols: FLJ41944, FLJ90611, GLLL6191, MGC87585, UNQ6191, envFRD, ERVFRDE1, HERV-FRD, HERV-W/FRD
Protein Interaction Partner: APP,
Protein Size: 538

Molecular Weight: 60 kDa

Gene ID: 405754

NCBI Accession: NM_207582, NP_997465

UniProt: P60508