P5CS antibody (N-Term)

Catalog No. ABIN2786580

The Rabbit Polyclonal anti-P5CS antibody has been validated for WB. It is suitable to detect P5CS in samples from Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for P5CS antibody (N-Term) (ABIN2786580)

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P5CS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-P5CS Antibody

Binding Specificity: N-Term

Sequence: SVIRHVRSWS NIPFITVPLS RTHGKSFAHR SELKHAKRIV VKLGSAVVTR

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ALDH18A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ALDH18A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 793 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for P5CS

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Alternative Name: ALDH18A1

Background: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases.This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
Alias Symbols: GSAS, MGC117316, P5CS, PYCS, ARCL3A
Protein Interaction Partner: CMTM5, AGTRAP, UBC, SUMO2, SUMO3, STAU1, MDM2, LATS2, ADRB2, VCP, TIMM13, SUMO1, NONO, MTHFD1, ILF3, ILF2, DDX1, CUL3, CDK2, SIRT7, TCF3, Haus1, Mical3, Trim69, Cbx1, HDAC5, MYC, ICT1, ZRANB1,
Protein Size: 793

Molecular Weight: 87 kDa

Gene ID: 5832

NCBI Accession: NM_001017423, NP_001017423

UniProt: P54886