PSMD3 antibody (Middle Region)

Catalog No. ABIN2786727

This anti-PSMD3 antibody is a Rabbit Polyclonal antibody detecting PSMD3 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for PSMD3 antibody (Middle Region) (ABIN2786727)

Target: PSMD3 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 (PSMD3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSMD3 Antibody

Binding Specificity: Middle Region

Sequence: YSTREPQLAF HQRISFCLDI HNMSVKAMRF PPKSYNKDLE SAEERREREQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PSMD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMD3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 534 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMD3

Target: PSMD3 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 3 (PSMD3))

Alternative Name: PSMD3

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.
Alias Symbols: P58, RPN3, S3, TSTA2
Protein Interaction Partner: CEP44, ZBTB43, HUWE1, SHFM1, SPRTN, SNAI2, STAU1, PSMD14, UBC, UBQLN1, FLNC, FLNB, PSMD8, PSMD4, PSMD1, PSMC6, PSMC5, PSMC4, PSMC3, PSMC2, PSMC1, KCMF1, UCHL5, KIAA0368, ADRM1, TXNL1, SQSTM1, RPS28, RPS21, RPS15A, RPS13, RPS8, PSMD12, PSMD11, PARK2, FBXO6
Protein Size: 534

Molecular Weight: 61 kDa

Gene ID: 5709

NCBI Accession: NM_002809, NP_002800

UniProt: O43242

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway