SH3BP2 antibody (Middle Region)

Catalog No. ABIN2786764

The Rabbit Polyclonal anti-SH3BP2 antibody (ABIN2786764) specifically detects SH3BP2 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig and Rabbit samples.

Quick Overview for SH3BP2 antibody (Middle Region) (ABIN2786764)

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3BP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SH3BP2 Antibody

Binding Specificity: Middle Region

Sequence: RQPSQADTGG DDSDEDYEKV PLPNSVFVNT TESCEVERLF KATSPRGEPQ

Predicted Reactivity: Cow: 85%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SH3BP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SH3BP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 561 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SH3BP2

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Alternative Name: SH3BP2

Background: SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism.
Alias Symbols: 3BP2, CRBM, CRPM, FLJ42079, RES4-23, 3BP-2
Protein Interaction Partner: RNF146, TNKS2, PDLIM7, TNKS, UBC, ERBB2, VAV1, SYK, SRC, CBL, SH3KBP1, DBNL, VAV3, LAT, VAV2, PLCG2, TF, ABL1, ZAP70, PLCG1, LCK, YWHAQ, FYN, FLT3, FGFR1, GRB2,
Protein Size: 561

Molecular Weight: 62 kDa

Gene ID: 6452

NCBI Accession: NM_003023, NP_003014

UniProt: P78314

Pathways: TCR Signaling