SH3BP2 antibody (AA 210-290)

Catalog No. ABIN7227094

This Rabbit Polyclonal antibody specifically detects SH3BP2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for SH3BP2 antibody (AA 210-290) (ABIN7227094)

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3BP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SH3BP2 Antibody

Binding Specificity: AA 210-290

Purpose: Rabbit Anti-3BP2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of 3BP2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human 3BP2 protein at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SH3BP2

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Alternative Name: 3BP2

Background: SH3 domain-binding protein 2, 3BP-2The protein encoded by SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in SH3BP2 result in cherubism. Multiple transcript variants encoding different isoforms have been found for SH3BP2.

Molecular Weight: 61kD

Gene ID: 6452

UniProt: P78314

Pathways: TCR Signaling