Mre11 antibody (Middle Region)

Catalog No. ABIN2786814

The Rabbit Polyclonal anti-Mre11 antibody (ABIN2786814) specifically detects Mre11 in WB. The antibody is reactive with Human, Rat, Mouse, Dog, Rabbit, Guinea Pig, Cow, Horse and Pig samples.

Quick Overview for Mre11 antibody (Middle Region) (ABIN2786814)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human, Rat, Mouse, Dog, Rabbit, Guinea Pig, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Mre11 Antibody

Binding Specificity: Middle Region

Sequence: RFRETRQKNT NEEDDEVREA MTRARALRSQ SEESASAFSA DDLMSIDLAE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against MRE11A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MRE11A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 708 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: MRE11A

Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: ATLD, HNGS1, MRE11, MRE11B
Protein Interaction Partner: HUWE1, CIAO1, ATRX, BRCA1, RPA3, RPA2, RPA1, EED, ABCF1, C14orf166, RTCB, RPL26L1, NELFB, IGF2BP3, LRRFIP1, MAP7, EIF2B2, EIF2B3, YBX3, RPL27, RFC4, QARS, NMT1, HNRNPM, ILF2, HNRNPU, HNRNPA2B1, FLII, DHX9, DDX1, LMNA, PAN2, UBC, MCM2, GINS1, MDC1, RNF8, C
Protein Size: 708

Molecular Weight: 80 kDa

Gene ID: 4361

NCBI Accession: NM_005591, NP_005582

UniProt: P49959

Pathways: DNA Damage Repair