TBC1D7 antibody (C-Term)

Catalog No. ABIN2786978

Product Details anti-TBC1D7 Antibody

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog, Goat, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ISRCFVKQLN NKYRDALPQL PKAFEQYLNL EDSRLLSHLK TCSAVSKLPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Tbc1d7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Tbc1d7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 293 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TBC1D7

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Alternative Name: Tbc1d7 (TBC1D7 Products)

Synonyms: PIG51 antibody, TBC7 antibody, dJ257A7.3 antibody, 2610009C09Rik antibody, TBC1 domain family member 7 antibody, TBC1 domain family, member 7 antibody, TBC1D7 antibody, Tbc1d7 antibody

Background: Tbc1d7 is a component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Alias Symbols: 2610009C09Rik
Protein Interaction Partner: Ywhae,
Protein Size: 293

Molecular Weight: 32 kDa

Gene ID: 67046

NCBI Accession: NM_025935, NP_080211

UniProt: Q9D0K0