PINX1 antibody (Middle Region)

Catalog No. ABIN2787041

This Rabbit Polyclonal antibody specifically detects PINX1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Pig, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for PINX1 antibody (Middle Region) (ABIN2787041)

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Pig, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PINX1 Antibody

Binding Specificity: Middle Region

Sequence: EKKSFSLEEK SKISKNRVHY MKFTKGKDLS SRSKTDLDCI FGKRQSKKTP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PINX1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PINX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 328 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PINX1

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Alternative Name: PINX1

Background: PINX1 is a microtubule-binding protein essential for faithful chromosome segregation. PINX1 mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. PINX1 inhibits telomerase activity and may inhibit cell proliferation and act as tumor suppressor.
Alias Symbols: FLJ20565, LPTL, LPTS, MGC8850
Protein Interaction Partner: UBC, CACYBP, TP63, GABPA, TERF1, DHX15, AIDA, MCRS1, PAFAH1B2, TERT, MPZ, HRNR, PLEKHJ1, PABPC1, GTPBP4, PABPC4, TXN, RPS28, RPS19, RPS16, RPS10, RPS3A, RPL31, RPL23A, CAPRIN1, CALM3, AHCY,
Protein Size: 328

Molecular Weight: 37 kDa

Gene ID: 54984

NCBI Accession: NM_017884, NP_060354

UniProt: Q96BK5