Tescalcin antibody (C-Term)

Catalog No. ABIN2787042

Product Details anti-Tescalcin Antibody

Target: Tescalcin (TESC)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Dog, Guinea Pig, Rabbit, Cow, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tescalcin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DSDGRITLEE YRNVVEELLS GNPHIEKESA RSIADGAMME AASVCMGQME

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 77%

Characteristics: This is a rabbit polyclonal antibody against TESC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TESC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Tescalcin

Target: Tescalcin (TESC)

Alternative Name: TESC (TESC Products)

Background: TESC functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. It promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane and promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. It is essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. It is also involved in granulocytic differentiation in a ERK-dependent manner and inhibits the phosphatase activity of calcineurin.
Alias Symbols: CHP3, TSC
Protein Interaction Partner: WBP11, UBC, CCDC91, HMG20A, TESC, RAI1, DYNLT3, SLC9A1,
Protein Size: 214

Molecular Weight: 23 kDa

Gene ID: 54997

NCBI Accession: NM_017899, NP_060369

UniProt: Q96BS2

Pathways: Proton Transport