H2AFY2 antibody (Middle Region)

Catalog No. ABIN785880

The Rabbit Polyclonal anti-H2AFY2 antibody (ABIN785880) specifically detects H2AFY2 in WB. The antibody is reactive with Human, Mouse, Rat, Guinea Pig, Rabbit, Horse, Cow and Dog samples.

Quick Overview for H2AFY2 antibody (Middle Region) (ABIN785880)

Target: H2AFY2 (H2A Histone Family, Member Y2 (H2AFY2))

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFY2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-H2AFY2 Antibody

Binding Specificity: Middle Region

Sequence: PRIHPELLAK KRGTKGKSET ILSPPPEKRG RKATSGKKGG KKSKAAKPRT

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against H2AFY2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human H2AFY2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 372 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for H2AFY2

Target: H2AFY2 (H2A Histone Family, Member Y2 (H2AFY2))

Alternative Name: H2AFY2

Background: H2AFY2 is the variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2AFY2 may be involved in stable X chromosome inactivation.
Alias Symbols: macroH2A2
Protein Interaction Partner: UBC, SUZ12, EED, WWP1, CBX5, DIDO1, SUMO1, HDGF, tat,
Protein Size: 372

Molecular Weight: 40 kDa

Gene ID: 55506

NCBI Accession: NM_018649, NP_061119

UniProt: Q9P0M6