CHMP1B antibody (N-Term)

Catalog No. ABIN2787213

The Rabbit Polyclonal anti-CHMP1B antibody has been validated for WB. It is suitable to detect CHMP1B in samples from Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio) and Guinea Pig.

Quick Overview for CHMP1B antibody (N-Term) (ABIN2787213)

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHMP1B Antibody

Binding Specificity: N-Term

Sequence: KIKKAIQKGN MEVARIHAEN AIRQKNQAVN FLRMSARVDA VAARVQTAVT

Predicted Reactivity: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CHMP1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHMP1B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 199 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHMP1B

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Alternative Name: CHMP1B

Background: CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).
Alias Symbols: C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2
Protein Interaction Partner: STAMBP, UBC, ATP6V1B1, CHMP4B, KNSTRN, CHMP1B, CHMP5, VPS4A, CNOT10, SNRNP200, SUCLG1, RAB11A, RASSF7, SSRP1, CHMP1A, USP54, USP8, SPAST, ELAVL1, IST1, VPS4B,
Protein Size: 199

Molecular Weight: 22 kDa

Gene ID: 57132

NCBI Accession: NM_020412, NP_065145

UniProt: Q7LBR1