CHMP1B antibody (N-Term)

Catalog No. ABIN2787213

The Rabbit Polyclonal anti-CHMP1B antibody is suitable to detect CHMP1B in samples from Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio) and Guinea Pig. It has been validated for WB.

Quick Overview for CHMP1B antibody (N-Term) (ABIN2787213)

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHMP1B Antibody

Binding Specificity: N-Term

Purpose: CHMP1B Antibody - N-terminal region

Sequence: KIKKAIQKGN MEVARIHAEN AIRQKNQAVN FLRMSARVDA VAARVQTAVT

Predicted Reactivity: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CHMP1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHMP1B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57408-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHMP1B

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Alternative Name: CHMP1B

Background:

Background Information: CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).

Gene Name: Charged multivesicular body protein 1B

Alternative Symbols: Vps46B, C10orf2, C18orf2, CHMP1.5, Vps46-2, C18-ORF2, hVps46-2

Protein Name: Charged multivesicular body protein 1b

Molecular Weight: 22kDa

Gene ID: 57132

NCBI Accession: NP_065145

UniProt: Q7LBR1