CHMP1B antibody (N-Term)

Catalog No. ABIN2787213

Product Details anti-CHMP1B Antibody

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP1B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KIKKAIQKGN MEVARIHAEN AIRQKNQAVN FLRMSARVDA VAARVQTAVT

Predicted Reactivity: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CHMP1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHMP1B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 199 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHMP1B

Target: CHMP1B (Charged Multivesicular Body Protein 1B (CHMP1B))

Alternative Name: CHMP1B (CHMP1B Products)

Synonyms: C10orf2 antibody, C18-ORF2 antibody, C18orf2 antibody, CHMP1.5 antibody, Vps46-2 antibody, Vps46B antibody, hVps46-2 antibody, 2810405I11Rik antibody, Chmp1b1 antibody, Chmp1.5 antibody, fb10c03 antibody, wu:fb10c03 antibody, zgc:56134 antibody, chromatin modifying protein 1b antibody, hypothetical protein antibody, charged multivesicular body protein 1B antibody, chromatin modifying protein 1B antibody, LOC692931 antibody, PGTG_18215 antibody, CHMP1B antibody, Chmp1b antibody, chmp1b antibody

Background: CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).
Alias Symbols: C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2
Protein Interaction Partner: STAMBP, UBC, ATP6V1B1, CHMP4B, KNSTRN, CHMP1B, CHMP5, VPS4A, CNOT10, SNRNP200, SUCLG1, RAB11A, RASSF7, SSRP1, CHMP1A, USP54, USP8, SPAST, ELAVL1, IST1, VPS4B,
Protein Size: 199

Molecular Weight: 22 kDa

Gene ID: 57132

NCBI Accession: NM_020412, NP_065145

UniProt: Q7LBR1