TRIB3 antibody (N-Term)

Catalog No. ABIN2787259

The Rabbit Polyclonal anti-TRIB3 antibody has been validated for WB. It is suitable to detect TRIB3 in samples from Human, Rat, Cow, Sheep, Guinea Pig, Rabbit and Dog.

Quick Overview for TRIB3 antibody (N-Term) (ABIN2787259)

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Reactivity: Human, Rat, Cow, Sheep, Guinea Pig, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIB3 Antibody

Binding Specificity: N-Term

Sequence: YVLLEPEEGG RAYQALHCPT GTEYTCKVYP VQEALAVLEP YARLPPHKHV

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Rabbit: 86%, Rat: 79%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against TRIB3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRIB3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 358 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Alternative Name: TRIB3

Background: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
Alias Symbols: C20orf97, NIPK, SINK, SKIP3, TRB3
Protein Interaction Partner: RPGRIP1, UBC, DDIT3, ATF4, RFWD2, PRMT5, AKT1, APP, SMURF1, CDC25A, BMPR2, SMAD3, BCL6, COPS6, RBM48, EEF1G, SETDB1, GIT1, GDF9, KAT5, AKT2, RELA, ATF5, HRSP12, TIAF1, MCM3AP, LTBP4, SIAH1, RBM4, PSMA3, RPSA, HLA-B, GRN, FN1, CSNK2B,
Protein Size: 358

Molecular Weight: 39 kDa

Gene ID: 57761

NCBI Accession: NM_021158, NP_066981

UniProt: Q96RU7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha