TRIB3 antibody (AA 152-325)

Catalog No. ABIN7173365

Product Details anti-TRIB3 Antibody

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Binding Specificity: AA 152-325

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tribbles homolog 3 protein (152-325AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Alternative Name: TRIB3 (TRIB3 Products)

Synonyms: zgc:76966 antibody, TRIB3 antibody, C20orf97 antibody, NIPK antibody, SINK antibody, SKIP3 antibody, TRB3 antibody, Ifld2 antibody, Nipk antibody, TRB-3 antibody, Trb3 antibody, tribbles pseudokinase 3 antibody, trib3 antibody, TRIB3 antibody, Trib3 antibody

Background:

Background: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the \\\'Thr-308\\\' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Aliases: C20orf97 antibody, Neuronal cell death inducible putative kinase antibody, Neuronal cell death-inducible putative kinase antibody, NIPK antibody, p65 interacting inhibitor of NF-kappaB antibody, p65-interacting inhibitor of NF-kappa-B antibody, SINK antibody, SKIP 3 antibody, SKIP3 antibody, TRB 3 antibody, TRB-3 antibody, TRB3 antibody, TRIB 3 antibody, Trib3 antibody, TRIB3_HUMAN antibody, Tribbles homolog 3 antibody, Tribbles pseudokinase 3 antibody, Tribbles3 antibody

UniProt: Q96RU7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha