OPA1 antibody (N-Term)

Catalog No. ABIN2787355

The Rabbit Polyclonal anti-OPA1 antibody (ABIN2787355) specifically detects OPA1 in WB. The antibody is reactive with Human, Rat, Mouse, Zebrafish (Danio rerio), Dog, Cow, Guinea Pig, Horse and Rabbit samples.

Quick Overview for OPA1 antibody (N-Term) (ABIN2787355)

Target: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OPA1 Antibody

Binding Specificity: N-Term

Purpose: OPA1 Antibody - N-terminal region

Sequence: SPEETAFRAT DRGSESDKHF RKVSDKEKID QLQEELLHTQ LKYQRILERL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against OPA1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57715-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for OPA1

Target: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Alternative Name: OPA1

Background:

Background Information: This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Optic atrophy 1 (autosomal dominant)

Alternative Symbols: NPG, NTG, MGM1, BERHS, largeG, MTDPS14

Protein Name: Mitochondrial dynamin-like 120 kDa protein EMBL ADP90061.1

Molecular Weight: 102kDa

Gene ID: 4976

NCBI Accession: NP_570844

UniProt: E5KLK2

Pathways: Tube Formation