PSMA3 antibody (Middle Region)

Catalog No. ABIN2787366

The Rabbit Polyclonal anti-PSMA3 antibody (ABIN2787366) specifically detects PSMA3 in WB. The antibody is reactive with Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse, Cow, Rabbit and Saccharomyces cerevisiae samples.

Quick Overview for PSMA3 antibody (Middle Region) (ABIN2787366)

Target: PSMA3 (Proteasome Subunit Alpha Type 3 (PSMA3))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse, Cow, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSMA3 Antibody

Binding Specificity: Middle Region

Sequence: TCRDIVKEVA KIIYIVHDEV KDKAFELELS WVGELTNGRH EIVPKDIREE

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 92%, Yeast: 77%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against PSMA3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 248 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMA3

Target: PSMA3 (Proteasome Subunit Alpha Type 3 (PSMA3))

Alternative Name: PSMA3

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA3 is a member of the peptidase T1A family, that is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Alias Symbols: HC8, MGC12306, MGC32631, PSC3
Protein Interaction Partner: SF1, STX4, SNRPC, SNRPB, RAB3IL1, PSMB4, PSMA6, PSMA3, PSMA1, NPPB, CTAGE5, LETM1, LASP1, KRAS, NPBWR2, GATA3, GATA2, CYBA, CST2, CDK6, ATP6V0C, DMC1, SLMO1, BTN2A2, STX6, SERF2, HUWE1, APLN, C1QTNF9B-AS1, C9orf106, KRTAP26-1, KRTAP19-5, KRTAP8-1, RTP5, R
Protein Size: 248

Molecular Weight: 28 kDa

Gene ID: 5684

NCBI Accession: NM_152132, NP_687033

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA