PDE8A antibody (C-Term)

Catalog No. ABIN2787371

This Rabbit Polyclonal antibody specifically detects PDE8A in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for PDE8A antibody (C-Term) (ABIN2787371)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE8A Antibody

Binding Specificity: C-Term

Sequence: SSNPYHNSTH SADVLHATAY FLSKERIKET LDPIDEVAAL IAATIHDVDH

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against PDE8A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDE8A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 829 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Alternative Name: PDE8A

Background: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000).
Alias Symbols: FLJ16150, HsT19550
Protein Interaction Partner: UBC,
Protein Size: 829

Molecular Weight: 91 kDa

Gene ID: 5151

NCBI Accession: NM_002605, NP_002596

UniProt: O60658

Pathways: cAMP Metabolic Process