ORC4 antibody (Middle Region)

Catalog No. ABIN2787391

Product Details anti-ORC4 Antibody

Target: ORC4 (Origin Recognition Complex, Subunit 4 (ORC4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VLEICLIIAM KHLNDIYEEE PFNFQMVYNE FQKFVQRKAH SVYNFEKPVV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ORC4L. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ORC4L

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 436 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ORC4

Target: ORC4 (Origin Recognition Complex, Subunit 4 (ORC4))

Alternative Name: ORC4L (ORC4 Products)

Background: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
Alias Symbols: ORC4, ORC4P, ORC4L
Protein Interaction Partner: RRM2B, TCF4, MCM3, MTUS1, MCM10, FBXL8, FBXO6, FBXO25, FBXL5, ORC3, ORC6, UBC, ORC5, ORC2, MLH1, MCM7, KPNA1, CTBP1, CDKN2A, CCND1, APP, XRCC5, XRCC6, CCL2, tat, MCM2, ORC1, MCM6, MCM4, DBF4, RPA2,
Protein Size: 436

Molecular Weight: 50 kDa

Gene ID: 5000

NCBI Accession: NM_181741, NP_859525

UniProt: O43929

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA