PER1 antibody (N-Term)

Catalog No. ABIN2787442

The Rabbit Polyclonal anti-PER1 antibody (ABIN2787442) specifically detects PER1 in WB. The antibody is reactive with Human, Mouse, Rat, Horse, Guinea Pig, Cow, Dog, Pig and Rabbit samples.

Quick Overview for PER1 antibody (N-Term) (ABIN2787442)

Target: PER1 (Period Homolog 1 (Drosophila) (PER1))

Reactivity: Human, Mouse, Rat, Horse, Guinea Pig, Cow, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PER1 Antibody

Binding Specificity: N-Term

Purpose: PER1 Antibody - N-terminal region

Sequence: SGPLEGADGG GDPRPGESFC PGGVPSPGPP QHRPCPGPSL ADDTDANSNG

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PER1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human PER1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57885-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PER1

Target: PER1 (Period Homolog 1 (Drosophila) (PER1))

Alternative Name: PER1

Background:

Background Information: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene, however, these variants have not been fully described.

Gene Name: period circadian clock 1

Alternative Symbols: PER, hPER, RIGUI

Protein Name: period circadian protein homolog 1

Molecular Weight: 32kDa

Gene ID: 5187

NCBI Accession: NP_002607

UniProt: O15534

Pathways: Photoperiodism