KDM2A antibody (Middle Region)

Catalog No. ABIN2787493

Product Details anti-KDM2A Antibody

Target: KDM2A (Lysine (K)-Specific Demethylase 2A (KDM2A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM2A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LTPPADKPGQ DNRSKLRNMT DFRLAGLDIT DATLRLIIRH MPLLSRLDLS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against KDM2A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human KDM2A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KDM2A

Target: KDM2A (Lysine (K)-Specific Demethylase 2A (KDM2A))

Alternative Name: KDM2A (KDM2A Products)

Synonyms: FBXL11 antibody, JHDM1A antibody, 100043628 antibody, 5530401A10Rik antibody, AA589516 antibody, AW536790 antibody, Cxxc8 antibody, Fbl11 antibody, Fbl7 antibody, Fbxl11 antibody, Gm4560 antibody, Jhdm1 antibody, Jhdm1a antibody, lalina antibody, KDM2A antibody, CXXC8 antibody, FBL11 antibody, FBL7 antibody, LILINA antibody, fb76b11 antibody, wu:fb76b11 antibody, wu:fj11c04 antibody, zgc:158441 antibody, zgc:158606 antibody, lysine demethylase 2A antibody, lysine (K)-specific demethylase 2A antibody, lysine (K)-specific demethylase 2Aa antibody, KDM2A antibody, Kdm2a antibody, kdm2aa antibody

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3.
Alias Symbols: CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Protein Interaction Partner: RB1, E2F1, EED, SKP1, MPG, ZNF512B, UBE2G2, SMAD7, SMAD3, HIST3H3, HIST2H3C, KIAA0368, ELAVL1, UBC, BCL6, FOS, RELA,
Protein Size: 620

Molecular Weight: 68 kDa

Gene ID: 22992

NCBI Accession: NM_012308, NP_036440

Pathways: Warburg Effect