KDM4B antibody (Middle Region)
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- Target See all KDM4B Antibodies
- KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Horse, Pig, Dog, Guinea Pig, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KDM4B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- SASRASLKAK LLRRSHRKRS QPKKPKPEDP KFPGEGTAGA ALLEEAGGSV
- Predicted Reactivity
- Cow: 92%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 82%, Pig: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against JMJD2B. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human JMJD2B
- Top Product
- Discover our top product KDM4B Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1096 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))
- Alternative Name
- JMJD2B (KDM4B Products)
- Synonyms
- KDM4B antibody, JMJD2B antibody, jmjd2b antibody, si:ch211-124a3.4 antibody, TDRD14B antibody, 4732474L06Rik antibody, Jmjd2b antibody, mKIAA0876 antibody, lysine demethylase 4B antibody, lysine (K)-specific demethylase 4B antibody, KDM4B antibody, kdm4b antibody, Kdm4b antibody
- Background
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JMJD2 family proteins are classified into one group with JD2H and TUDOR domains and another group without JD2H or TUDOR domains. Because JMJD2C gene (also known as GASC1 gene) is amplified in esophageal squamous cell carcinoma (ESCC), JMJD2 family genes are cancer-associated genes. Human genes corresponding to KIAA0677, KIAA0876, KIAA0780 and FLJ10251 cDNAs were designated JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. In addition, JMJD2D homologous genes within human genome sequences AP002383.3 and AP001264.4 were designated JMJD2E and JMJD2F, respectively. C2HC2HC2- and C5HC2-type Cys (His) clusters were identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins. JMJD2A, JMJD2B and JMJD2C consist of JmjN, JmjC, JD2H, and two TUDOR domains.
Alias Symbols: FLJ44906, KDM4B, KIAA0876, JMJD2B
Protein Interaction Partner: UBC, H3F3C, HSP90B1, HSP90AA2P, SMU1, KMT2C, WDR5, ASH2L, KMT2D, RBBP5, HSPA4, HNRNPU, ESR1, MED10,
Protein Size: 1096 - Molecular Weight
- 122 kDa
- Gene ID
- 23030
- NCBI Accession
- NM_015015, NP_055830
- UniProt
- O94953
- Pathways
- Warburg Effect
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